The YouTube video titled "Refusal Skills" emphasizes the importance of developing the ability to say no to risky behaviors, such as the consumption of alcohol and other drugs. It discusses why refusal skills are crucial and provides guidance on how to effectively resist peer pressure and avoid engaging in harmful activities. This content is particularly relevant for prevention professionals, as it offers strategies to empower individuals, especially youth, to make safe and healthy choices, thereby reducing the likelihood of substance abuse and other negative outcomes.